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It is now well accepted that changing levels of certain metabolites can alter histone and DNA modifications resulting in changes in gene expression

Accordingly, missense DNA mutations that impair G6PD activity or stability result in increased oxidative stress and a spectrum of disease phenotypes featuring, most commonly, hemolytic anemia, and collectively called G6PD deficiency 1

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Des tudes ont montr qu'une supplmentation en glutathion peut amliorer les marqueurs enzymatiques hpatiques chez les patients atteints de statose hpatique non alcoolique et favoriser la gurison aprs diverses expositions toxiques

Statements Author contributions PW: Data Curation, Formal Analysis, Investigation, Methodology, Visualization, Writing original draft, Writing review & editing

These linkers enhance plasma stability, rendering them less susceptible to the chemical or enzymatic environment in vivo following the internalization of ADCs by target cells [144, 145]