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Centrilobular and panlobular emphysemas are associated with increased dyspnea and hyperinflation, decreased walking distance, and lower diffusing capacity

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Under conditions of severe metabolic stresssuch as anoxia and ATP depletion during myocardial ischemia, stroke, or cellular injuryvesicular storage of neurotransmitters is severely impaired (Silver et al., 2001)

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Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria