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When cells face oxidative stress or electrophilic compounds, critical cysteine residues in Keap1 become modified, causing conformational changes that reduce NRF2 ubiquitination

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Hydrogen peroxide scavenging activity Figure 8 compares the hydrogen peroxide scavenging activity of P

Innate immune activation, which includes macrophage polarization and adaptive immune perturbations, exacerbates glomerulosclerosis and interstitial fibrosis through cytokine storms and mitochondrial oxidative stress

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Besides inhibition of oligodendrocyte precursor cell migration (Novgorodov et al., 2007), through S1PR1s and S1PR5s regulation, fingolimod also regulates survival, differentiation, and the extension of the cellular process in oligodendrocyte progenitors (Jaillard et al., 2005