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Since vitamin D facilitates calcium absorption, there is a tendency that it will cause gastrointestinal distress and lead to a buildup of calcium

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Clinical trials have shown promising results, highlighting its effectiveness in improving glycemic control and aiding weight loss in individuals with Type 2 diabetes and obesity

It does not act through a single receptor pathway

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[16] Although cyanocobalamin lacks a defined upper-toxicity threshold due to its water solubility and renal elimination, exceptionally high cumulative doses have been temporally associated with acneiform eruptions, altered potassium homeostasis, and theoretical thrombotic risk, emphasizing the importance of evidence-based dosing