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Intestinal barrier function: Molecular regulation and disease pathogenesis

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Additionally, the antibody was improved with a silenced IgG4 Fc, which does not deplete or interfere with the normal effectors (80)

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According to the study of Chen, IncRNA NEAT1 induces sorafenib resistance of HCC patients through repressing miR-335 expression and activation of c-Met-Akt signaling pathway (Shao et al., 2015) and the combination of HGF and c-Met inhibitors and sorefenib could improve the efficacy of the first line systemic treatment ( In conclusion, although the tivantinib phase III trial failed and the reason is not clear, the role of c-Met inhibitors in treating HCC can not be denied

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