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Additionally, tirzepatide improved quality-of-life scores and reduced the incidence of sleep-related cardiovascular events

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Synaptic efficacy in the VTA and NAc is central to drug-induced neuroadaptations, and GLP-1RAs may reverse or attenuate these maladaptive changes by modulating excitatory/inhibitory balance [7,31]

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227 Determining whether GLP-1 has direct/indirect effects on islet alpha-cells and what receptor(s) mediate these actions requires further investigation

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