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22 , 29, 30, 31 On the basis of this rationale, several clinical trials have been conducted and the results showed that hypomethylating agents (e.g., guadecitabine, decitabine, and azacitidine) can partially restore sensitivity to platinum agents in patients with PROC.32, 33, 34, 35, 36 Besides, transmembrane protein 88 (TMEM88), gelsolin and FANCF promoter hypomethylation are associated with platinum resistance in OC.37, 38, 39 Nuclear CD55 is reported to bind to and suppress ZMYND8 expression, thus derepressing PRC2 to increase H3K27me3, leading to platinum resistance in OC

Incidence of X-linked adrenoleukodystrophy and the relative frequency of its phenotypes

and Type V, although less common, is characterized by fat distribution predominantly in the calves Notably, some literature also describes involvement of the lower abdomen, especially in Types I and II, although this is not consistently reflected across all classification systems.8,15,21,22 Regarding morphological appearance, lipedema progresses through four clinical stages (Table 2): Stage I is characterized by smooth skin with thickened but soft subcutaneous tissue containing small nodules

For the dilution benchmark experiment (Fig

BPC-157 is a synthetic peptide derived from a protective protein found naturally in gastric juice

Biochem Genet 63 , 936959 (2025)