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Why Tirzepatide Causes Nausea and How Your Body Adapts Tirzepatide activates GLP-1 and GIP receptors in your gut and brain, which slows the rate food moves through your stomach

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In addition, the incretin hormones slow gastric emptying, thereby delaying the absorption of food (and, in particular, glucose) a further mechanism in reducing post-meal hyperglycaemia

2019 Sep;42(9):1724-1732

Type 2 diabetes itself is a major risk factor for erectile dysfunction due to vascular complications, autonomic neuropathy, and reduced nitric oxide bioavailability