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Low StO2 directly hinders hypoxia induced factors (the HIF) from degrading, hence its accumulation triggers subsequent signaling cascades in response to hypoxia (68)

Evidence Strength Definition: Strong: Consistent human RCTs with low bias + clear microbiota-depression mediation

the Passive avoidance test and constant-start versions of the MWM that did not require hippocampal processing and the standard MWM task that relied on hippocampal processing

Ellwardt E, Walsh JT, Kipnis J, Zipp F (2016)

Since Vitamin B12 is mostly taken in with animal products such as meats, shellfish, dairy and eggs, people who abstain from animal based proteins are more commonly afflicted

E., Kim C