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Why it happens: Slowed stomach emptying together with smaller, low-fat meals can reduce natural stool-stimulating signals

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Participants in these trials also followed a reduced-calorie diet and a robust exercise program, aiming for 150 minutes per week

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In the study, participants with a responsive genetic score had an 82% increase in the likelihood of acheiving weight loss with a GLP-1 medication.[ref] Another study showed that GLP1 receptor variants are associated with greater weight loss on GLP-1 RA drugs.[ref] Common genetic variants in the GLP1R (GLP-1 receptor) gene impact weight and type 2 diabetes risk

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This leads to pain, stiffness, and reduced mobility in affected joints

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Discussing lifestyle factors, including alcohol intake, diet, and physical activity levels

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