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The failure of two major formaldehyde catabolism enzymes (ADH5 and ALDH2) leads to partial synthetic lethality in C57BL/6 mice

in order to limit time to freezing (and potential changes in metabolic phenotype due to death) no additional processing of tissue occurred and organs were not perfused prior to collection

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On this occasion, the authors expand our understanding of glutathione biology and identify extracellular glutathione (GSH), abundant in the tumour microenvironment, as an alternative source of essential amino acids to sustain tumour cell proliferation

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