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Phytofurans Under increased oxygen tension, such as in highly oxygenated tissues like lung, brain, and kidneys, cyclic nonenzymatic metabolites possessing a substituted tetrahydrofuran ring (PhytoFs) are preferentially formed compared to phytoprostanes

Nat Rev Microbiol 15:385396 Fan Z, Wirth AK, Chen D, Wruck CJ, Rauh M, Buchfelder M, Savaskan N (2017) Nrf2-keap1 pathway promotes cell proliferation and diminishes ferroptosis

Proteomic and bioinformatic analyses illustrate that deficiency in the PCYT1A, a gene abundantly expressed in Mller cells of the INL, dysregulates the activity of the metabolism of retinal fatty acids and ferroptosis-related pathways (70)

Hagos FT, Daood MJ, Ocque JA, Nolin TD, Bayir H, Poloyac SM, et al

9 Recent studies have estimated that arresting PD progression would result in net monetary benefits of almost $450,000 per patient, and if PD progression was slowed by 20%, a benefit of over $75,000 per patient would be realized

doi: 10.1016/j.tips.2018.02.007 128 PhensyA.DriskillC.LindquistK.GuoL.JeevakumarV.FowlerB.et al