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In fact, its probably the biggest barrier to increasing use of this medication. For physicians, another large challenge when prescribing GLP-1RA medications includes lack of clinical guidelines for offlabel prescribing

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Obese individuals have an increased risk of morbidity because of the various related disorders, including diabetes, cardiovascular events, stroke, cancer, and obstructive sleep apnea (Must et al., 2009

Ania Jastreboff, associate professor at Yale School of Medicine and obesity medicine physician-scientist, tells TODAY.com

This is regardless of the existence of co-morbid conditions

According to an exclusive interview with the TODAY show on Thursday, Williams has already started to see her health improve since starting the medication