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Moreover, our experiments further verified the role of Nrf2 by using Nrf2-shRNA, Nrf2 agonists, antioxidant and Nrf2 knockout mice, confirming that the protective effects of AZI on CS-induced airway epithelial barrier dysfunction primarily depends on the activation of Nrf2/GCL/GSH signaling pathway

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The results have ranged from incredible, hand-carved meerschaum masterpieces to carbon fiber pipes that look more like supercar accessories than something to smoke tobacco in and a dizzying variety of pocket pipes that prove size isn't everything