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Xie, Z., Yang, S., Deng, W., Li, J., & Chen, J

While proper hydration is important, excessive water intake (more than 3-4 litres daily) without electrolyte replacement could potentially cause electrolyte imbalances

That is not a small difference

A 2025 study presented at ENDO (the Endocrine Society's annual meeting) confirmed that approximately 40% of weight lost from semaglutide comes from lean mass, with women and older adults at higher risk

At a Glance: GLP-1 Gastric Slowing & Relief The Mechanism: GLP-1 receptor agonists delay gastric emptying, meaning food moves slower through your digestive tract, absorbing excess water and causing hard stools