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The efficacy of GLP-1s has made them a breakthrough not only in managing obesity and diabetes, but also in their potential to treat several related conditions

Some state or regional plans may have more lenient or more strict policies regarding the off-label use of high-cost drugs

The SURMOUNT-5 head to head trial confirmed this pattern

The oral formulation comes with specific requirements

Some practitioners implement cycling to theoretically prevent receptor desensitization, provide physiological breaks, or manage costs, though evidence supporting these approaches is limited

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