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Studies have shown that quercetin is a classic activator of the nuclear factor E2-related factor 2 (Nrf2) pathway and can significantly enhance the activity of intracellular antioxidant enzymes (such as superoxide dismutase and catalase) (Wang et al., 2017)

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26 The trial began with single and multiple dose ascending stages in healthy volunteers and extended to elderly non-PD participants in June 2024 to control for age-related effects

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A recent study found that APP/PS1 mice fed with a TMAO-supplemented diet manifested reduced occludin and ZO-1 expression in the parietal cortex, along with increased microglial and astrocytic activation