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When released after eating, GLP-1 signals the pancreas to produce insulin, reduces the release of glucagon, slows stomach emptying, and communicates with the brain to increase feelings of fullness

Side effects and gaps in follow-up care are also causing disruptions in medication use, according to CHOPs findings, recently published in the journal Pediatrics

Coexpression of glucagon-like peptide-1 (GLP-1) receptor, vasopressin, and oxytocin mRNAs in neurons of the rat hypothalamic supraoptic and paraventricular nuclei: effect of GLP-1(7-36)amide on vasopressin and oxytocin release

Ensure the clinical story is consistent: if metformin wasnt used or wasnt tolerated, document the intolerance/contraindication and reflect it in the drug history and rationale

Some things to watch out for in the legal market: Safety and monitoring are by no means foolproof

Esther Walden, deputy head of care at Diabetes UK, said the shortages are disappointing but welcomed the government guidance