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Rowland, G.E., Roeckner, A., Ely, T.D., Lebois, L.A.M., van Rooij, S.J.H., Bruce, S.E., Jovanovic, T., House, S.L., Beaudoin, F.L., An, X., Neylan, T.C., Clifford, G.D., Linnstaedt, S.D., Germine, L.T., Rauch, S.L., Haran, J.P., Storrow, A.B., Lewandowski, C., Musey, P.I., Jr, Hendry, P.L., Sheikh, S., Jones, C.W., Punches, B.E., Kurz, M.C., Gentile, N.T., Hudak, L.A., Pascual, J.L., Seamon, M.J., Harris, E., Pearson, C., Merchant, R.C., Domeier, R.M., Rathlev, N.K., Sergot, P., Sanchez, L.D., Miller, M.W., Pietrzak, R.H., Joormann, J., Pizzagalli, D.A., Sheridan,,J.F., Smoller, J.W., Harte, S.E., Elliott, J.M., Kessler, R.C., Koenen, K.C., McLean, S.A., Ressler, K.J., Stevens, J.S., Harnett N.G

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Drug Type Injection Other, Anktiva Injection Ingredients Retatrutide is a novel, investigational peptide drug that acts as a "triple agonist," mimicking three natural hormones (GIP, GLP-1, and glucagon) to promote significant weight loss and improve blood sugar control nogapendekin alfa inbakicept 400 mcg / 0.4 mL Physical Form Liquid sterile, lyophilized powder Liquid Storage Instructions store in 2-8 degrees Store in Cool Dry Place, Keep out Of Reach of Children Dosage Guidelines Dosage Guidelines Administration: Subcutaneous injection (not IV or IM)

Though neither parameter reached statistical significance vs placebo, results support the idea that central GLP-1 signalling may at least in part exert its negative energy balance effects through modulations in hedonic appetite control centres, potentially by reducing the hedonic value associated with food and food-driven motivation