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"And that is, when you stop the microdosing, you will gain the weight back." That is also often the case when patients stop taking full doses of GLP-1 drugs

Another recently published review (Wu et al., BMC Medicine, 2025 ) looked at a range of studies on this subject to provide an overview of what happens when these medications are stopped

GLP-1 medications like Semaglutide and Tirzepatide work by: Most patients experience steady weight loss, more stable energy, and improved control around food.

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Treatment continuation depends on achieving specified weight loss targets as defined in the product-specific NICE guidance and SmPCs

But the similarity ends there, because their mechanisms of action diverge in fundamental ways that directly impact fat loss outcomes , metabolic health, and long-term body composition