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The cumulative frequency distributions of change in body weight are shown in Figure 3, Figure 4, Figure 5 and Figure 6 for Studies 2, 3, 7 and 8

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Physical examination now demonstrated significant right lower extremity edema, a destructive gangrenous ulcer of most of the right plantar foot, and numerous violaceous papules over the dorsal and plantar foot surfaces (Figures 3 and 4)

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This minimum requirement becomes the de facto standard

However, like any medication, there may be potential side effects, and its important to discuss the risks and benefits with your healthcare provider