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Description
The cumulative frequency distributions of change in body weight are shown in Figure 3, Figure 4, Figure 5 and Figure 6 for Studies 2, 3, 7 and 8

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Physical examination now demonstrated significant right lower extremity edema, a destructive gangrenous ulcer of most of the right plantar foot, and numerous violaceous papules over the dorsal and plantar foot surfaces (Figures 3 and 4)

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This minimum requirement becomes the de facto standard

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